TRU Block, the most powerful active blocker on the market today, actively blocks Heterophilic Antibody (HA) interference in immunoassays including, but not limited to, Human Anti-Mouse Antibody (HAMA) interference.
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What is Heterophilic Antibody Interference?
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- Heterophilic Antibodies are a group of human antibodies against animal IgG. HA interference is a well known interference factor in diagnostic assays, often causing false positive results.
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- The most known Heterophilic Antibody interference is HAMA. HA to other animals such as Goat (HAGA), Sheep (HASA), Rabbit (HARA), etc. may also cause false results.
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- The frequency of such interference is low, but the false results have significant impact on the quality and competitiveness of the diagnostic assays as well as on the lives of those individuals who have been falsely diagnosed.
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What is the difference between TRU Block and Mouse IgG? |
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TRU Block |
Mouse IgG |
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- Uses a proprietary active mechanism to inhibit HAMA
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- Inhibits HAMA by serving as antigens of HAMA
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- Works well on HAMA as well as other types of HA
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- Effective on HAMA but not on other types of HA
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- Much lower concentration is needed than Mouse IgG (5-20 times less)
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- Higher concentration is needed than TRU Block
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